John Dye of Wysox last saw his wife Karen Thursday morning.
And he says nothing seemed out of the ordinary.
"I had a bag of garbage outside, she took that and dumped that in the garbage and she brought the dog in," Dye said.
Dye says his wife left the house around 11.
She didn't say good-bye, but Dye says that was normal.
"To leave in the morning to go do errands, that was a normal thing. She would usually leave to go Dunkin Donuts, bring me back coffee, so I think think anything when she left," Dye said.
Dye was last seen at this CVS Pharmacy in Towanda around 11:30 Thursday Morning.
The receipt shows she picked up some diabetes medication.
When police discovered her van the next day, the medication was inside, but Dye was no where to be found.
The minivan was found around 3 o'clock Friday afternoon parked here at the Wysox boat landing along the Susquehanna River.
But Pennsylvania State Police believe it had been there since Thursday afternoon.
Besides the medication, the keys and some personal belongings were all inside.
Area fire departments searched the river over the weekend, but so far, nothings turned up.
Back at the Dye House, Karen's husband says he's still trying to make sense of it all.
"We were the best of friends, and everything there were no problems here, that's why I say it's out of the ordinary for her," Dye said.
And now all he can do is try to stay positive, and hope for the best.