The indictments end a year and a half investigation.
In late December, police carried out several raids that broke up two separate drug rings.
You're seeing a home and a motel that were targeted.
In all police found about two pounds of cocaine, more than 10 thousand in cash.
Most of the people arrested were from Ithaca and New York City.
While announcing their indictments in Ithaca, State Attorney General Andrew Cuomo said it's a big dent in drug trade between down and upstate.
"This is an epidemic, we have to address it, we have to address it statewide, and to the extent people are coming up from New York City and they think they have an opportunity in Ithaca, they are exactly wrong," says Cuomo.
In all, 37 people face prosecution.
One suspected drug kingpin is 32 year old Isaac Butler of Ithaca.
He faces 24 years in prison if convicted.
The other accused ring leader is 22 year old Charlie Watford of Brooklyn who faces 15 years in prison.