It was on Interstate 88 in Sidney Tuesday night.
29 year old Jaime Rudnitsky of Otego died.
State police say Rudnitsky was headed the wrong way, driving west in the east bound lanes.
Her car first hit a tractor trailer, causing a chain reaction crash.
Two other people were injured and taken to Fox Hospital in Oneonta.
52 year old Steven Ranuado of Oneonta is stable condition.
26 year old Jeremy Ranaudo was released today.
Fox says Steve works there as a speech therapist, and Jaime Rudnitksy had worked as a nurses aide.