The Binghamton Fire Department received a call at about 6:30, that a home at 18 Chestnut Street was on fire.
Firefighters found heavy smoke when they arrived.
And say two children, their mother, and possibly her parents got out of the home in time.
Chief Daniel Thomas says the fire was difficult to get to, as it spread between the second floor ceiling and the roof.
Firefighters used chainsaws and axes to open up holes in the roof, to fight the fire from above.
"It's a battle. Very labor intensive to get to the fire here. You can see by the number of firemen. The heat of the day here so far, fortunately it's not hotter than it is but it really takes a toll on them, but it's a very labor intensive fire," says Binghamton Fire Chief Dan Thomas.
The home isn't livable.
The extent of the damage isn't known at the time.
Chief Thomas says the family will be staying at his home, which is right across the street.