It happened here on Route 79 in Center Lisle at about 2:45 Friday afternoon.
New York State police say a maroon Ford Mustang was traveling eastbound when it crossed over the yellow line and into the path of an oncoming tractor trailer.
The driver of the Mustang was pronounced dead at the scene.
The driver of the tractor trailer was uninjured.
The victim's name has not been released.
We'll have the very latest Saturday on Action News at 6.