It happened on State Route 187 just north of Dry Run Road in Wysox Township around 11:00 AM Friday.
Pennsylvania State Police in Towanda say Nathen Dailey, 25, was traveling north on State Route 187.
Dailey lost control of his vehicle, a 2002 Oldsmobile Alero, which traveled into the southbound lane.
It struck a 2008 Freightliner cattle truck on the driver's side.
The truck was operated by Steven LaValley, 36.
Dailey was pronounced dead at the scene.
A passenger in his vehicle was seriously injured.
The passenger's name has not been released.
The person was taken by helicopter to Robert Packer Hospital in Sayre.
LaValley was not injured.
All three people involved in the accident were wearing seat belts.