According to sportsbooks, the San Francisco 49ers (2-0) are double-digit, 10.5-point favorites heading into their matchup on Thursday, September 21, 2023 against the New York Giants (1-1). For this matchup, the over/under has been set at 43.5 points.

The recent betting insights and trends for the 49ers can be seen below before you wager on their matchup against Giants. Before the Giants square off against the 49ers, prepare for the matchup by taking a look at their recent betting trends and insights.

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Giants vs. 49ers Odds, Spread, Over/Under

Check out the odds, spread and over/under for this matchup at several sportsbooks.

Favorite Total San Francisco Moneyline New York Moneyline
BetMGM 49ers (-10.5) 43.5 -600 +425 Bet on this game with BetMGM
FanDuel 49ers (-10.5) 43.5 -650 +480 Bet on this game with FanDuel

Other Week 3 Odds

New York vs. San Francisco Game Info

  • When: Thursday, September 21, 2023 at 8:15 PM ET
  • Where: Levi's Stadium in Santa Clara, California
  • TV Info: Amazon Prime Video
  • Live Stream: Watch this game on Fubo!

Giants vs. 49ers Betting Insights

  • New York's record against the spread last season was 13-4-0.
  • The Giants covered the spread when playing as at least 10.5-point underdogs in their only opportunity last season.
  • Last season, seven of New York's 17 games went over the point total.
  • San Francisco was 11-6-0 against the spread last season.
  • The 49ers went unbeaten ATS (1-0) as a 10.5-point favorite or more last year.
  • There were nine San Francisco games (out of 17) that hit the over last season.

Giants Player Props

Name Pass Yds Pass TDs Rush Yds Rush TDs Rec Yds Rec TDs
Darren Waller - - - - 45.5 (-115) -
Matt Breida - - 31.5 (-118) - 12.5 (-118) -
Parris Campbell - - - - 27.5 (-118) -
Daniel Jones 215.5 (-115) 1.5 (+170) - - - -
Darius Slayton - - - - 35.5 (-118) -
Isaiah Hodgins - - - - 31.5 (-115) -

Payouts above are for the "over" bet.

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